Medicinal Chemistry 1 Semester 4 Notes as per PCI Syllabus | Download Free B Pharmacy Pdf Notes Semester Wise

Medicinal Chemistry 1 Semester 4 Notes as per PCI Syllabus | Download Free B Pharmacy Pdf Notes Semester Wise 

Follow us on :-
The Pharma Courses:-  Click here
Facebook:- Click here 
Instagram:- Click here 
YouTube:- Click here  
Telegram:- Click here  
Email- help@thepharmacourses.com

Scope:

This subject is designed to impart fundamental knowledge on the structure, chemistry and therapeutic value of drugs. The subject emphasizes on structure activity relationships of drugs, importance of physicochemical properties and metabolism of drugs. The syllabus also emphasizes on chemical synthesis of important drugs under each class 

Objectives: Upon completion of the course student shall be able:

1. understand the chemistry of drugs with respect to their pharmacological activity

2. understand the drug metabolic pathways, adverse effect and therapeutic value of

drugs

3. know the Structural Activity Relationship (SAR) of different class of drugs

4. write the chemical synthesis of some drugs

Download Semester wise PDFs,MCQs and Notes :-
Semester 1 :- Click here 
Semester  2 :- Click here 
Semester  3 :- Click here 
Semester  4 :- Click here 
Semester  5 :- Click here 
Semester  6 :- Click here 
Semester  7 :- Click here 
Semester  8 :- Click here

Syllabus Content:

UNIT- I

Introduction to Medicinal Chemistry

History and development of medicinal chemistry

Physicochemical properties in relation to biological action

Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and Geometrical isomerism.

Drug metabolism Drug metabolism

principles- Phase I and Phase II. Factors affecting drug metabolism including stereo chemical aspects.

 

UNIT- II

Drugs acting on Autonomic Nervous System

Adrenergic Neurotransmitters:

Biosynthesis and catabolism of catecholamine. Adrenergic receptors (Alpha & Beta) and their distribution. Sympathomimetic agents: SAR of

Sympathomimetic agents Direct acting: Nor-epinephrine, Epinephrine, Phenylephrine*, Dopamine, Methyldopa, Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol*, Bitolterol, Naphazoline, Oxymetazoline and Xylometazoline. · Indirect acting agents: Hydroxyamphetamine, Pseudoephedrine, Propylhexedrine. · Agents with mixed mechanism: Ephedrine, Metaraminol.

Adrenergic Antagonists:

Alpha adrenergic blockers: Tolazoline*, Phentolamine, Phenoxybenzamine, Prazosin, Dihydroergotamine, Methysergide.

Beta adrenergic blockers: SAR of beta blockers, Propranolol*, Metibranolol, Atenolol, Betazolol, Bisoprolol, Esmolol, Metoprolol, Labetolol, Carvedilol.

 

UNIT-III

Cholinergic neurotransmitters:

Biosynthesis and catabolism of acetylcholine. Cholinergic receptors (Muscarinic & Nicotinic) and their distribution.

Parasympathomimetic agents: SAR of Parasympathomimetic agents

Direct acting agents: Acetylcholine, Carbachol*, Bethanechol, Methacholine, Pilocarpine.

Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible): Physostigmine, Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion.

Cholinesterase reactivator: Pralidoxime chloride.

Cholinergic Blocking agents: SAR of cholinolytic agents

Solanaceous alkaloids and analogues: Atropine sulphate, Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.

Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide, Dicyclomine hydrochloride*, Glycopyrrolate, Methantheline bromide, Propantheline bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride.

 

UNIT- IV

Drugs acting on Central Nervous System

A.    Sedatives and Hypnotics:

Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem

Barbiturtes: SAR of barbiturates, Barbital*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital

Miscelleneous: Amides & imides: Glutethmide. Alcohol & their carbamate derivatives: Meprobomate, Ethchlorvynol. Aldehyde & their derivatives: Triclofos sodium, Paraldehyde.

B.    Antipsychotics

Phenothiazeines: SAR of Phenothiazeines - Promazine hydrochloride, Chlorpromazine hydrochloride*, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride.

Ring Analogues of Phenothiazeines: Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine.

Fluro buterophenones: Haloperidol, Droperidol, Risperidone. Beta amino ketones: Molindone hydrochloride.

Benzamides: Sulpieride.

 

C.    Anticonvulsants: SAR of Anticonvulsants, mechanism of anticonvulsant action

Barbiturates: Phenobarbitone, Methabarbital.

Hydantoins: Phenytoin*, Mephenytoin, Ethotoin

Oxazolidine diones: Trimethadione, Paramethadione

Succinimides: Phensuximide, Methsuximide, Ethosuximide*

Urea and monoacylureas: Phenacemide, Carbamazepine* Benzodiazepines: Clonazepam

Miscellaneous: Primidone, Valproic acid , Gabapentin, Felbamate

 

UNIT – V

Drugs acting on Central Nervous System General anesthetics:

Inhalation anesthetics: Halothane*, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane.

Ultra short acting barbitutrates: Methohexital sodium*, Thiamylal sodium, Thiopental sodium.

Dissociative anesthetics: Ketamine hydrochloride.*

Narcotic and non-narcotic analgesics Morphine and related drugs: SAR of Morphine analogues, Morphine sulphate, Codeine, Meperidine hydrochloride, Anilerdine hydrochloride, Diphenoxylate hydrochloride, Loperamide hydrochloride, Fentanyl citrate*, Methadone hydrochloride*, Propoxyphene hydrochloride, Pentazocine, Levorphanol tartarate.

Narcotic antagonists: Nalorphine hydrochloride, Levallorphan tartarate, Naloxone hydrochloride.

Anti-inflammatory agents: Sodium salicylate, Aspirin, Mefenamic acid*, Meclofenamate, Indomethacin, Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen*, Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone.

Download Following chapters:-

UNIT- I

Physicochemical properties in relation to biological action

Download

Drug metabolism Drug metabolism

Download(Coming Soon)

UNIT- II

Adrenergic Neurotransmitters

Download(Coming Soon)

Sympathomimetic agents Direct acting

Download(Coming Soon)

Adrenergic Antagonists (All Points)

Download

UNIT-III

Cholinergic neurotransmitters:

Download

Parasympathomimetic agents

Download 
Download (optional link)

Cholinergic Blocking agents (All Topic)

Download

UNIT- IV

A.    Sedatives and Hypnotics:(All Chapters) 

Download

Antipsychotics

Download

Anticonvulsants (All Topic)

Download

UNIT – V

Drugs acting on Central Nervous System General anesthetics (All Topic)

Download

Narcotic antagonists

Download

Check other important B Pharm Notes:-

Human Anatomy and Physiology-I :- Click here 

Pharmaceutical Organic Chemistry :- Click here 

Medicinal Chemistry :-Click here 

Organic chemistry:- Click here 

Pharmaceutical Analysis:- Click here 

Cosmetic Notes:- Click here 

Pharmacology:- Click here 

Pharmaceutics :- Click here 

Pharmacognosy:- Click here 

Microbiology :-Click Here

Biochemistry :-Click Here

Pharmaceutical Inorganic Chemistry:-Click Here

Medicinal Chemistry 1 :-Click Here

If you need additional notes please comment below or if you need any information related to pharmacy field kindly contact us or follows us on our social media accounts