Biopharmaceutics and Pharmacokinetics sem 6 part 1 (01-50) MCQs with Answers for B pharmacy students as per PCI Syllabus | Free MCQs for GPAT and NIPER
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1. Which one of the following mechanisms shows saturation or mixed order kinetics?
A. Pore transport
B. Passive diffusion
C. Carrier mediated transport
D. Endocytosis
2. The order for dissolution of different solid forms of drugs is
A. Amorphous>Metastable> Stable
B. Stable > Metasatble> Amorphous
C. Metastable > Stable > Amorphous
D. Amorphous > Stable > Metastable
3. Astrocytes and pericytes are the specialized cells of
A. Blood-CSF barrier
B. Blood brain barrier
c. Blood placental barrier
D. Capillary endothelial barrier
4. Following are phase II reactions of metabolism except
A. Glucuronidation
B. Glycine Cojugation
C. Reduction
D. Sulphation
5. The agents excreted in urine are not
A. Hydrophilic
B. Non-volatile
C. Lipophilic
D. Metabolized slowly
6. If the renal clearance is <130ml/min, what will be the probable mechanism of renal excretion?
A. Drug filtered and reabsorbed partially
B. Filtration and secretion only
C. Only filtration
D. Clearance equal to renal plasma flow rate
7. If molecular weight of a drug is 300 to 500 Daltons it is excreted by
A. Kidney
B. Bile
C. Both of the above
D. None of the above
8. The subtstantial degradation of an orally administered drug caused by enzyme metabolism in the liver before the drug reaches the systemic circulation is called as
A. First-pass effect
B. Disposition
C. Antagonism
D. Glucuronidation
9. The release exponent 'n' value of 0.5 in Korsemeyer Peppas equation indicates
A. Anomalous transport
B. Zero order release
C. Fickian diffusion
D. Super case II transport
10. According to one of the following theories, the eddies or packets of solvents absorb the solute and carry it to the bulk of the solution
A. Film theory
B. Surface renewal theory
C. Interfacial barrier model
D. Ph-partition theory
11. According to USP the dissolution apparatus 5 is
A. Reciprocating cylinder
B. Flow-through cell
C. Paddle over disc
D. Cylinder
12. Which drug transport mechanism is involved in intestinal absorption of vitamins B1 & B2
A. Pore transport
B. Passive diffusion
C. Carrier mediated transport
D. Endocytosis
13. The volume of blood that flows per unit time per unit volume of the tissue is called as
A. Volume of distribution
B. Clearance
C. Perfusion rate
D. Glomerular filtration rate
14. The highest category of correlation of IVIVC is
A. Level A correlation
B. Level B correlation
C. Level C correlation
D. Level D correlation
15. Two or more drug products having equivalent bioavailability represents
A. Chemical equivalence
B. Pharmaceutical equivalence
C. Therapeutic equivalence
D. Bioequivalence
16. In which study design each subject is administered the test and standard formulation?
A. 2- way cross over design
B. 3- way cross over design
C. 4-way cross over design
D. All of the above
17. An exemption for conducting a bioequivalence study is called as
A. Biowaiver
B. Biosimilar
C. Biodiversity
D. None of the above
18. The most important parameter in determination of bioavailability is
A. Onset of action
B. Onset time
C. Therapeutic range
D. Area under curve
19. Which of the following statement is true?
A. Ideally for optimum absorption, a drug should have sufficient aqueous solubility to dissolve in aqueous GI fluid and lipophilicity high enough to permeate across biomembranes and into systemic circulation.
B. Ideally for optimum absorption, a drug should have sufficient permeability to dissolve in aqueous GI fluid and solubility high enough to permeate across biomembrane and into systemic circulation.
C. A perfect hydrophilic-lipophilic balance should be there in the structure of the drug for optimum bioavailability
D. Both a and c
20. The surface area of small intestine is approximately
A. 0.1-0.2 sq.m
B. 200 sq.m
C. 0.15 sq.m
D. 0.30 sq.m
21. Which of the following is not a mechanism for pharmacokinetic analysis?
a) Compartment analysis
b) Non compartment analysis
c)Physiologic modeling
d) Human model
22. Proteins interact with which part of the cell membrane?
a) Hydrophobic tail
b) Polar head
c) Non polar head
d) Hydrophilic tail
23. Which part of the membrane is responsible for the relative impermeability of polar molecules in and out of the cell?
a) Polar head
b) Hydrophobic head
c) Hydrophobic core
d) Non polar head
24. What helps in the passing of inorganic ions?
a) lon channels
b) Voltage gated channels
c) Aqueous filled pores
d) Diffusion
25. The cell membrane is ,
a) Impermeable
b) Semipermeable
c) Permeable
d) Permeable to only gases
26. What is the most important characteristic of a drug to be absorbed after ora administration?
a) Dissolved in HCL
b) Dissolved in alkaline solution
c) Can pass through the cell membrane
d) Form aggregate and settle down
27. Which one of these is an example of Enteral Route?
a) Skin
b) IV
c) Gastrointestinal
d) Inhalation
28. Gastrointestinal route is an example of which of the major drug delivery routes?
a) The enteral route
b) The parenteral route
c) The topical route
d) The intravenous route
29. Which is the major process of absorption for more than 90% of drugs?
a) Facilitated diffusion
b) Active transport
c) Endocytosis
d) Passive diffusion
30. What is the driving force for Passive Diffusion?
a) Concentration gradient only
b) Electrochemical gradient only
c) Charge equilibration and concentration gradient
d) Concentration and Electrochemical gradient both
31. Which kind of molecules cannot pass through a pore transport?
a) Low Molecular weight molecules
b) Water-soluble drugs
c) Molecules up to 400 Dalton
d) Molecules greater than 400 Dalton
32. What is the driving force of Pore Transport?
a) Hydrostatic pressure
b) Concentration Gradient
c) Electrochemical gradient
d) Charge equilibration
33. What will be the best definition for "carrier"?
a) Nonpolar drugs can be transported through carrier-mediated transport
b) Carrier binds reversibly and no covalently with the molecules
c) It discharges the molecules and gets destroyed itself
d) The carrier is a protein
34. What is the major difference between Facilitated diffusion and Passive diffusion?
a) Carrier-mediated transport
b) Downhill transport
c) Energy is used
d) Inhibition by metabolic poisons
35. What influences the permeation of drugs in an lonic or Electrochemical diffusion?
a) Charge on the membrane
b) Charge on the particle
c) Concentration gradient
d) Equilibration of charge
36. Which kind of drugs are absorbed through endocytosis?
a) Molecular weight ranging 100-400Dalton
b) Water-soluble drugs
c) Macromolecular drugs or drugs as oily droplets
d) Polar drugs
37. Which drugs are absorbed through pore transport?
a) High lipophilicity
b) Water-soluble drugs of molecular weight less than 100 Dalton
c) Oily droplets
d) Affinity for carriers
38. Which of these absorption methods involves engulfing of the extracellular drug?
a) Endocytosis
b) Passive diffusion
c)Facilitated diffusion
d) lon-Pair transport
39. Which is the other name of "cell eating"?
a) Transcytosis
b) Phagocytosis
c) Pinocytosis
d) Endocytosis
40. Which one of these is a physicochemical property of Drug substance?
a) Drug solubility
b) Disintegration time
c) Age of patient
d) Dissolution time
41. Which one of these does not come under a physicochemical property of drugs?
a) Drug solubility
b) Disintegration time
c) Dissolution rate
d) Drug stability
42. In the sequenee of events in the drug absorption from orally administered solid dosage, which one comes at first?
a) Disintegration
b) Disaggregation
c) Dissolution
d) Absorption
43. Which one is the correct sequence for drug absorption through the oral route?
a) Absorption - Dissolution - Disintegration - Deaggregation
b) Disintegration - Dissolution - Deaggregation - Absorption
c) Disintegration - Deaggregation - Dissolution - Absorption
d) Disintegration - Deaggregation - Absorption - Dissolution
44. The rate at which drug reaches the systemic circulation is determined by the slowest of the various steps involved in the sequence. This is known as.
a) Disintegration timne
b) Dissolution time
c) Rate limiting step
d) Gastric Emptying time
45. Which sentence will define the Dissolution rate?
a) Amount of solid substrate that goes into solution under constant time
b) Amount of solid substrate that goes into solution under constant time under standard temperature
c) Amount of solid substrate that goes into solution under constant time under standard
temperature, pH, and pressure
d) Amount of solid substrate that goes into solution under constant time under standard temperature, pH, solvent composition and constant surface area
46. What should be the ideal solubility rate of an orally administered drug in the pH range of 2 to 8?
a) 3-4mg/ml
b) 4-6 mg/ml
c) 7-8 mg/ml
d) 1-2 mg/ml
47. Which one of these is not a theory of Drug dissolution?
a) Diffusion layer model
b) Fick's law of diffusion
c) Penetration or surface renewal theory
d) Interfacial barrier model
48. Which theory takes into account that a thin film is created by the solution of the solid at the solid-liquid interface?
a) Interfacial barrier model
b) Diffusion layer model
c) Penetration or surface renewal theory
d) Danckwert's model
49. In the equation G=Ki (Cs-Cb), what does G stands for_
a) Dissolution rate per unit area
b) Effective interfacial transport constant
c) Concentration of the solute
d) Concentration of the impurity
50. Which model does not approve the existence of the stagnant layer in the solid-liquid interface?
a) Interfacial barrier model
b) Diffusion layer mode
c) Penetration or surface renewal theory
d) Danckwert's model
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